What is the best process for creating, opening, editing, etc PDFs from within Visual Studio 2008?

I am the project manager on a web-based application that will need to:

1. Create, open, edit, save, etc PDFs from within a Visual Studio 2008 web application (Visual Basic).
2. Populate PDFs from SQL server 2010 database.
3. Allow users to use PDF editing tools from within the website.

BTW, the application is being written in Visual Basic.

Will the SDK allow us to do this? What licenses do we need to purchase?

Are there 3rd party plugins that make doing these things much faster and simpler?

Any input is GREATLY appreciated!!!

Sincerely,

Mike